Ms. Ferheen Baig
Ferheen is a Research Assistant and Part time PhD student in the Cardiovascular Division at King’s College London where she works within Prof Manuel Mayr’s Proteomics group, providing support on all mass spectrometry related projects. Her role includes developing methods for untargeted and targeted nano-LC-MS/MS for the discovery and analysis of extracellular matrix proteins in samples from cardiovascular disease and related disorders.
As well as carrying out research for her PhD project, she is responsible for developing novel ‘fit for purpose’ targeted MRM methods for the quantification of extracellular matrix proteins, including their glycosylations, fragmentation and isoforms.
After receiving a BSc in Biomedical Science from King’s College and an MSc in Forensic Science from London South Bank University, Ferheen was employed by the pharmaceutical industry for 7 years where she worked mainly on small molecules as a bioanalyst for Drug Metabolism & Pharmacokinteic (DMPK) departments at GlaxoSmithKline and more recently at Novartis. Towards the end of her time at Novartis she began working on biomarker quantification including large molecules, prompting her interest in proteomics.
Education
| 2001-2004 | BSc (Honours) Biomedical Science, Kings College London, UK |
| 2004-2005 | MSc Forensic Science, London South Bank University, UK |
Present Appointment
| 2014- | Research Assistant, Cardiovascular Division, King’s College London, UK |
Previous Appointment
| 2012-2014 | Protein & Biomarker LCMS Scientist, Metabolism & Pharmacokinetics, NOVARTIS, Horsham, UK |
| 2009-2012 | Bioanalytical Scientist, Metabolism & Pharmacokinetics, NOVARTIS, Horsham, UK |
| 2006-2009 | Bioanalytical Associate , Drug Metabolism & Pharmacokinetics, GLAXOSMITHKLINE, Ware, UK |
Publications
| 1 | Theofilatos K, Stojkovic S, Hasman M, van der Laan SW, Baig F, Barallobre-Barreiro J, Schmidt LE, Yin S, Yin X, Burnap S, Singh B, Popham J, Harkot O, Kampf S, Nackenhorst MC, Strassl A, Loewe C, Demyanets S, Neumayer C, Bilban M, Hengstenberg C, Huber K, Pasterkamp G, Wojta J, Mayr M. Proteomic Atlas of Atherosclerosis: The Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes, and Outcomes. Circulation Research. 2023 133(7) : 542-558. [Full Text] [PubMed] [DOI] |
| 2 | Joshi A, Schmidt LE, Burnap SA, Lu R, Chan MV, Armstrong PC, Baig F, Gutmann C, Willeit P, Santer P, Barwari T, Theofilatos K, Kiechl S, Willeit J, Warner T, Mathur A, Mayr M. Neutrophil-Derived Protein S100A8/A9 Alters the Platelet Proteome in Acute Myocardial Infarction and Is Associated With Changes in Platelet Reactivity. Arteriosclerosis, thrombosis, and vascular biology. 2021 : ATVBAHA-121. [Full Text] [PubMed] [DOI] |
| 3 | Barallobre-Barreiro J, Radovits T, Fava M, Mayr U, Lin WY, Ermolaeva E, Martínez-López D, Lindberg EL, Duregotti E, Daróczi L, Hasman M, Schmidt LE, Singh B, Lu R, Baig F, Siedlar AM, Cuello F, Catibog N, Theofilatos K, Shah AM, Crespo-Leiro MG, Doménech N, Hübner N, Merkely BP, Mayr M. The Extracellular Matrix in Heart Failure: The Role of Adamts5 In Proteoglycan Remodelling. Circulation. 2021 : . [Full Text] [PubMed] [DOI] |
| 4 | Ghim M, Pang KT, Burnap SA, Baig F, Yin X, Arshad M, Mayr M, Weinberg PD. Endothelial cells exposed to atheroprotective flow secrete follistatin-like 1 protein which reduces transcytosis and inflammation. Atherosclerosis. 2021 333 : 56-66. [Full Text] [PubMed] [DOI] |
| 5 | Yin X, Wanga S, Fellows AL, Barallobre-Barreiro J, Lu R, Davaapil H, Franken R, Fava M, Baig F, Skroblin P, Xing Q, Koolbergen DR, Groenink M, Zwinderman AH, Balm R, de Vries CJM, Mulder BJM, Viner R, Jahangiri M, Reinhardt DP, Sinha S, de Waard V, Mayr M.. Glycoproteomic Analysis of the Aortic Extracellular Matrix in Marfan Patients.. Arterioscler Thromb Vasc Biol.. 2019 39(9) : 1859-1873. [Full Text] [PubMed] [DOI] |
| 6 | Barwari T, Eminaga S, Mayr U, Lu R, Armstrong PC, Chan MV, Sahraei M, Fernández-Fuertes M, Moreau T, Barallobre-Barreiro J, Lynch M, Yin X, Schulte C, Baig F, Pechlaner R, Langley SR, Zampetaki A, Santer P, Weger M, Plasenzotti R, Schosserer M, Grillari J, Kiechl S, Willeit J, Shah AM, Ghevaert C, Warner TD, Fernández-Hernando C, Suárez Y, Mayr M. Inhibition of profibrotic microRNA-21 affects platelets and their releasate. JCI Insight. 2018 3 : e123335. [Full Text] [PubMed] [DOI] |
| 7 | Fava M, Barallobre-Barreiro J, Mayr U, Lu R, Didangelos A, Baig F, Lynch M, Catibog N, Joshi A, Barwari T, Yin X, Jahangiri M, Mayr M. Role of ADAMTS (A Disintegrin and Metalloproteinase With Thrombospondin Motifs)-5 in Aortic Dilatation and Extracellular Matrix Remodeling. Arterioscler Thromb Vasc Biol. 2018 38 : 1537-1548. [Full Text] [PubMed] [DOI] |
| 8 | Suna G, Wojakowski W, Lynch M, Barallobre-Barreiro J, Yin X, Mayr U, Baig F, Lu R, Fava M, Hayward R, Molenaar C, White SJ, Roleder T, Milewski K, Gasior P, Buszman PP, Buszman PE, Jahangiri M, Shanahan C, Hill JM, Mayr M. Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries. Circulation. 2018 137 : 166-183. [Full Text] [PubMed] [DOI] |
| 9 | Yin X, Baig F, Haudebourg E, Blankley RT, Gandhi T, Müller S, Reiter L, Hinterwirth H, Pechlaner R, Tsimikas S, Santer P, Willeit J, Kiechl S, Witztum JL, Sullivan A, Mayr M. Plasma Proteomics for Epidemiology: Increasing Throughput With Standard-Flow Rates. Circ Cardiovasc Genet. 2017 10 : e001808. [Full Text] [PubMed] [DOI] |
| 10 | Baig F, Mayr M. What are the prospects of apolipoprotein profiling for cardiovascular disease?. Expert Rev Mol Diagn. 2017 Epub : ahead of print. [Full Text] [PubMed] [DOI] |
| 11 | Barallobre-Barreiro J, Baig F, Fava M, Yin X, Mayr M. Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry. J Vis Exp. 2017 122 : . [Full Text] [PubMed] [DOI] |
| 12 | Pechlaner R, Tsimikas S, Yin X, Willeit P, Baig F, Santer P, Oberhollenzer F, Egger G, Witztum JL, Alexander VJ, Willeit J, Kiechl S, Mayr M. Very-Low-Density Lipoprotein-Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III. J Am Coll Cardiol. 2017 69 : 789-800. [Full Text] [PubMed] [DOI] |
| 13 | Baig F, Joshi A, Mayr M. High Density Lipoproteins in High Resolution: Will Proteomics Solve the Paradox for Cardiovascular Risk?. Proteomics. 2017 17 : 3-4. [Full Text] [PubMed] [DOI] |
| 14 | Baig F, Pechlaner R, Mayr M. Caveats of Untargeted Metabolomics for Biomarker Discovery. J Am Coll Cardiol. 2016 68 : 1294-1296. [Full Text] [PubMed] [DOI] |
| 15 | Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X, Barwari T, Potier D, Albadawi H, Jahangiri M, Porter K, Watkins M, Misra S, Stoughton J, Mayr M. Extracellular Matrix Remodeling in Response to Venous Hypertension: Proteomics of Human Varicose Veins. Cardiovasc Res. 2016 110 : 419-430. [Full Text] [PubMed] [DOI] |
| 16 | Baig F, Mayr M. What can we learn from metabolomics?. Heart Metab. 2015 67 : 21-25. [Full Text] |